Yes, but it breaks so many other tools that it is basically not worth. For example, all shell shortcuts (Ctrl+A, Ctrl+E, Ctrl+W etc.).
Neither me nor anybody in my company found a viable solution which is to ultimately learn to use cmd for certain things on Mac (like copy/paste).
If you likes it takes two, in march the same studio should release “split fiction”.
Other titles that come to mind: cuphead, untitled goose game, overcooked (!), valheim.